Overview:
The Clinical Toxicology laboratory provides testing and consultative services for a variety of toxicological analyses, among them:
- Bioanalysis to provide definitive identification and quantification
- Toxins, therapeutic drugs and biomarkers of oxidant stress (utilizing mass spectral libraries of more than 50,000 drugs, toxins and their metabolites)
- Other specialized bioanalyses, including renal calculi and unknown substances by FTIR infrared spectroscopy
- Pharmacokinetic interpretation and reporting.
Pharmacokinetic software coupled with faculty review and interpretation is utilized to generate interpretative reports for busulfan testing and special requests for individual drug pharmacokinetic analyses.
Highlights:
- A national reference laboratory for busulfan pharmacokinetic testing
- A regional reference laboratory for sirolimus therapeutic drug monitoring
- One of the first U.S. academic centers to introduce mycophenolic acid therapeutic drug monitoring, including interpretative reporting; testing program serves as a reference laboratory for unusual poisoning cases at Delaware Valley hospitals
- Ongoing development of new test procedures in the Xenobiotic Toxicokinetic research laboratory
- Major Alzheimers Disease testing center involving 800 patients and 49 sites throughout the US and Canada
- Weekly case conference for residents highlights instructive cases in therapeutic drug monitoring and clinical toxicology.
Contact:
Location: 7 Founders
Leslie M Shaw, PhD, Director
215-662-6575
shawlmj@mail.med.upenn.edu
